Clinical Trials

Advancing clinical evidence for EEG-guided neuromodulation

Wave Neuroscience conducts and supports clinical research exploring how EEG-guided neuromodulation and individualized brain network measurements may help inform more personalized approaches to brain stimulation. Through collaborations with clinicians, researchers, and academic institutions, we continue to expand research into biomarker-guided neuromodulation.

PTSD

EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.
Status
Currently Recruiting
ClinicalTrials.gov ID
NCT06892028
Sponsor
Wright State University
Study Start
2025-02-12
Study Completion
2026-01-31
(Estimated)
Enrollment
110
PTSD

eTMS for Veterans and First Responders With PTSD

A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.
Status
Currently Recruiting
ClinicalTrials.gov ID
NCT06294106
Sponsor
Virginia Polytechnic Institute and State University
Study Start
2024-06-10
Study Completion
2026-04-01
(Estimated)
Enrollment
20
PTSD

EEG Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder

This is an open-label safety pilot study of the Electroencephalogram (EEG) Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 30 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 10 in-office visits that take place over 21 total days. Two eTMS treatment sessions are administered during each office visit.
Status
Completed
ClinicalTrials.gov ID
NCT06081309
Sponsor
Wright State University
Study Start
2023-11-20
Study Completion
2024-05-16
Enrollment
30
PTSD

Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder (MeRT-005-B)

The purpose of this study is to evaluate the safety and efficacy of individualized, Biometrics-guided Magnetic e-Resonance Therapy (MeRT) treatment of Post-Traumatic Stress Disorder
Status
Completed
ClinicalTrials.gov ID
NCT02990793
Sponsor
Texas A&M
Study Start
2022-04-04
Study Completion
2025-11-04
Enrollment
158

Clinical research partners

Texas A&M University Institute of Biosciences and Technology logo
Wright State University logo
Tomahawk Charitable Solutions logo
Fralin Biomedical Research Institute at VTC, Virginia Tech logo
University of the Sunshine Coast Australia logo
Special Operations Care Fund (SOC-F) logo